Bianconi Daniela, Unseld Matthias, Prager Gerald W
Department of Internal Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, A-1090 Vienna, Austria.
Int J Mol Sci. 2016 Dec 6;17(12):2037. doi: 10.3390/ijms17122037.
Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the . In this review, we will discuss the contribution of integrins to these hallmarks, including uncontrolled and limitless proliferation, invasion of tumor cells, promotion of tumor angiogenesis and evasion of apoptosis and resistance to growth suppressors, by highlighting the latest findings. Further on, given the paramount role of integrins in cancer, we will present novel strategies for integrin inhibition that are starting to emerge, promising a hopeful future regarding cancer treatment.
整合素是异二聚体细胞表面受体，根据其组成与不同的细胞外配体结合，并调节所有支持多细胞生命的过程。在癌症中，整合素触发并在所有曾被描述为……的特征中发挥关键作用。在本综述中，我们将通过强调最新发现，讨论整合素对这些特征的贡献，包括不受控制的无限增殖、肿瘤细胞侵袭、促进肿瘤血管生成以及逃避凋亡和对生长抑制因子的抗性。此外，鉴于整合素在癌症中的至关重要作用，我们将介绍开始出现的整合素抑制新策略，有望为癌症治疗带来充满希望的未来。
