Budisan Liviuta, Gulei Diana, Zanoaga Oana Mihaela, Irimie Alexandra Iulia, Sergiu Chira, Braicu Cornelia, Gherman Claudia Diana, Berindan-Neagoe Ioana
Research Center for Functional Genomics, Biomedicine and Translational Medicine, University of Medicine and Pharmacy "Iuliu-Hatieganu", 400012 Cluj-Napoca, Romania.
MEDFUTURE-Research Center for Advanced Medicine, University of Medicine and Pharmacy "Iuliu-Hatieganu", 400012 Cluj-Napoca, Romania.
Int J Mol Sci. 2017 Jun 1;18(6):1178. doi: 10.3390/ijms18061178.
Phytochemicals are natural compounds synthesized as secondary metabolites in plants, representing an important source of molecules with a wide range of therapeutic applications. These natural agents are important regulators of key pathological processes/conditions, including cancer, as they are able to modulate the expression of coding and non-coding transcripts with an oncogenic or tumour suppressor role. These natural agents are currently exploited for the development of therapeutic strategies alone or in tandem with conventional treatments for cancer. The aim of this paper is to review the recent studies regarding the role of these natural phytochemicals in different processes related to cancer inhibition, including apoptosis activation, angiogenesis and metastasis suppression. From the large palette of phytochemicals we selected epigallocatechin gallate (EGCG), caffeic acid phenethyl ester (CAPE), genistein, morin and kaempferol, due to their increased activity in modulating multiple coding and non-coding genes, targeting the main hallmarks of cancer.
植物化学物质是植物中作为次生代谢产物合成的天然化合物，是具有广泛治疗应用的重要分子来源。这些天然物质是关键病理过程/病症（包括癌症）的重要调节因子，因为它们能够调节具有致癌或肿瘤抑制作用的编码和非编码转录本的表达。目前，这些天然物质单独或与癌症的传统治疗方法联合用于开发治疗策略。本文的目的是综述近期关于这些天然植物化学物质在与癌症抑制相关的不同过程中的作用的研究，包括凋亡激活、血管生成和转移抑制。从众多植物化学物质中，我们选择了表没食子儿茶素没食子酸酯（EGCG）、咖啡酸苯乙酯（CAPE）、染料木黄酮、桑色素和山奈酚，因为它们在调节多个编码和非编码基因方面活性增强，靶向癌症的主要特征。
