Bu Zhang-Yu, Yu Xiao-Hong, Wu Li-Min, Zhong Jian-Bo, Yang Ping, Chen Jian
Department of Dermatology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China.
Exp Ther Med. 2017 Jun;13(6):3327-3332. doi: 10.3892/etm.2017.4418. Epub 2017 May 3.
The purpose of this study was to investigate the changes in peripheral blood regulatory T (Treg) cells, serum transforming growth factor-β1 (TGF-β1), and lymphotactin (LTN) following treatment of patients with condyloma acuminata (CA) with 5-aminolevulinic acid-photodynamic. A total of 46 patients with CA were selected as the experimental group and 43 healthy individuals were included in the control group. Before the treatment, the CA patients had a higher number of CD4CD25Foxp3 Treg cells and CD4CD25 Treg cells than the healthy group. CA patients also had lower levels of serum TGF-β1 and LTN than the healthy controls. After the treatment, the number of CD4CD25Foxp3 Treg cells and CD4CD25 Treg cells decreased significantly in the CA patients and normalized to the levels in the control group after 3 weeks. The treatment also elevated the levels of serum TGF-β1 and LTN in the CA patients, which were close to the values in the control group after 3 weeks. The results showed that low levels of serum TGF-β1 and LTN played important roles in the occurrence and development of CA and cellular immune functions were closely related to the occurrence and development of CA.
本研究旨在探讨5-氨基酮戊酸光动力疗法治疗尖锐湿疣（CA）患者后外周血调节性T（Treg）细胞、血清转化生长因子-β1（TGF-β1）和淋巴细胞趋化因子（LTN）的变化。共选取46例CA患者作为实验组，43例健康个体作为对照组。治疗前，CA患者的CD4CD25Foxp3 Treg细胞和CD4CD25 Treg细胞数量高于健康组。CA患者的血清TGF-β1和LTN水平也低于健康对照组。治疗后，CA患者的CD4CD25Foxp3 Treg细胞和CD4CD25 Treg细胞数量显著减少，并在3周后恢复至对照组水平。治疗还提高了CA患者血清TGF-β1和LTN的水平，3周后接近对照组值。结果表明，血清TGF-β1和LTN水平低下在CA的发生发展中起重要作用，细胞免疫功能与CA的发生发展密切相关。
