1 Department of Prevention, Rehabilitation and Sports Medicine, Technische Universität München, Germany.
2 Department of Cardiology, Klinikum Garmisch-Partenkirchen, Germany.
Eur J Prev Cardiol. 2017 Aug;24(12):1328-1335. doi: 10.1177/2047487317713326. Epub 2017 Jun 6.
Background In contrast to the well-accepted benefits of moderate exercise, recent research has suggested potential deleterious effects of repeated marathon running on the cardiovascular system. We thus performed a comprehensive analysis of markers of subclinical vascular damage in a cohort of runners having finished multiple marathon races successfully. Design This was a prospective, observational study. Methods A total of 97 healthy male Munich marathon participants (mean age 44 ± 10 years) underwent detailed training history, cardiopulmonary exercise testing for assessment of peak oxygen uptake, ultrasound for assessment of intima-media-thickness as well as non-invasive assessments of ankle-brachial index, augmentation index, pulse wave velocity and reactive hyperaemia index. Results Runners had previously completed a median of eight (range 1-500) half marathons, six (1-100) full marathons and three (1-40) ultramarathons; mean weekly and annual training volumes were 59 ± 23 and 1639 ± 979 km. Mean peak oxygen uptake was 50 ± 8 ml/min/kg, and the Munich marathon was finished in 3:45 ± 0:32 h. Runners showed normal mean values for intima-media-thickness (0.60 ± 0.14 mm), ankle-brachial index (1.2 ± 0.1), augmentation index (17 ± 13%), pulse wave velocity (8.7 ± 1.4 cm/s) and reactive hyperaemia index (1.96 ± 0.50). Age was significantly and independently associated with intima-media-thickness ( r = 0.531; p < 0.001), augmentation index ( r = 0.593; p < 0.001) and pulse wave velocity ( r = 0.357; p < 0.001). However, no independent associations of peak oxygen uptake, marathon finishing time, number of completed races or weekly and annual training km with any of the vascular parameters were observed. Conclusions In this cohort of healthy male runners, running multiple marathon races did not pose an additional risk factor for premature subclinical vascular impairment beyond age.
与适度运动带来的益处形成鲜明对比的是，最近的研究表明，反复进行马拉松跑步可能对心血管系统造成有害影响。因此，我们对一组成功完成多次马拉松比赛的跑步者进行了亚临床血管损伤标志物的综合分析。
这是一项前瞻性、观察性研究。
共有 97 名健康的慕尼黑马拉松参与者（平均年龄 44±10 岁）接受了详细的训练史、心肺运动测试以评估峰值摄氧量、超声检查以评估内膜中层厚度以及踝臂指数、增强指数、脉搏波速度和反应性充血指数的非侵入性评估。
跑步者之前已经完成了中位数为 8 次（范围 1-500 次）半程马拉松、6 次（1-100 次）全程马拉松和 3 次（1-40 次）超马拉松；平均每周和每年的训练量分别为 59±23 和 1639±979 公里。平均峰值摄氧量为 50±8ml/min/kg，慕尼黑马拉松的完赛时间为 3:45±0:32 小时。跑步者的内膜中层厚度（0.60±0.14mm）、踝臂指数（1.2±0.1）、增强指数（17±13%）、脉搏波速度（8.7±1.4cm/s）和反应性充血指数（1.96±0.50）均处于正常均值。年龄与内膜中层厚度（ r=0.531;p<0.001）、增强指数（ r=0.593;p<0.001）和脉搏波速度（ r=0.357;p<0.001）呈显著的独立相关性。然而，峰值摄氧量、马拉松完赛时间、完成比赛次数或每周和每年的训练公里数与任何血管参数均无独立相关性。
在这组健康的男性跑步者中，多次完成马拉松比赛不会增加除年龄以外的过早亚临床血管损伤的风险因素。
