Rubies Cira, Batlle Montserrat, Sanz-de la Garza Maria, Dantas Ana-Paula, Jorba Ignasi, Fernandez Guerau, Sangüesa Gemma, Abuli Marc, Brugada Josep, Sitges Marta, Navajas Daniel, Mont Lluís, Guasch Eduard
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
Centro de Investigación Biomédica en Red - Cardiovascular (CIBERCV), Madrid, Spain.
JACC Basic Transl Sci. 2022 Jul 13;7(7):681-693. doi: 10.1016/j.jacbts.2022.02.017. eCollection 2022 Jul.
Moderate exercise has well-founded benefits in cardiovascular health. However, increasing, yet controversial, evidence suggests that extremely trained athletes may not be protected from cardiovascular events as much as moderately trained individuals. In our rodent model, intensive but not moderate training promoted aorta and carotid stiffening and elastic lamina ruptures, tunica media thickening of intramyocardial arteries, and an imbalance between vasoconstrictor and relaxation agents. An up-regulation of angiotensin-converter enzyme, miR-212, miR-132, and miR-146b might account for this deleterious remodeling. Most changes remained after a 4-week detraining. In conclusion, our results suggest that intensive training blunts the benefits of moderate exercise.
适度运动对心血管健康有充分的益处。然而，越来越多且存在争议的证据表明，与适度训练的个体相比，训练过度的运动员可能无法像他们那样免受心血管事件的影响。在我们的啮齿动物模型中，高强度而非适度训练会促进主动脉和颈动脉僵硬以及弹性层破裂、心肌内动脉的中膜增厚，以及血管收缩剂和舒张剂之间的失衡。血管紧张素转换酶、miR-212、miR-132和miR-146b的上调可能是这种有害重塑的原因。在4周的停训后，大多数变化仍然存在。总之，我们的结果表明，高强度训练会削弱适度运动的益处。
