Heyman M B, Vichinsky E, Katz R, Gaffield B, Hurst D, Castillo R, Chiu D, Kleman K, Ammann A J, Thaler M M
Lancet. 1985 Apr 20;1(8434):903-6. doi: 10.1016/s0140-6736(85)91677-0.
The effect of increased nutritional intake was evaluated in 5 growth-retarded children with sickle-cell disease. Growth on recommended daily calorie and protein intakes had been inadequate in all 5. Fat absorption and intestinal mucosal morphology were normal in all 5. 2 children were given nutritional supplementation by nasogastric intubation, 1 received nightly oral formula supplements, and 2 were supplemented with zinc, iron, folate, and vitamin E only. Nutritional supplementation by the nasogastric route produced a rapid sustained increase in growth rate, associated with striking reductions in pain crises and infections which had previously necessitated many hospital admissions. Oral supplementation improved the clinical course but had no effect on growth rate. Mineral and vitamin supplements influenced neither the growth rate nor the clinical course. The observations indicate that nasogastric nutritional supplementation may accelerate growth and reduce the incidence and severity of complications in growth-retarded children with sickle-cell disease.
对5名患有镰状细胞病且生长发育迟缓的儿童进行了营养摄入量增加效果的评估。所有5名儿童按照推荐的每日卡路里和蛋白质摄入量生长均不充足。这5名儿童的脂肪吸收和肠道黏膜形态均正常。2名儿童通过鼻胃管进行营养补充，1名儿童每晚口服配方奶补充剂，另外2名儿童仅补充锌、铁、叶酸和维生素E。通过鼻胃管途径进行营养补充使生长速率迅速持续增加，同时疼痛危机和感染显著减少，而此前这些情况导致多次住院治疗。口服补充改善了临床病程，但对生长速率没有影响。矿物质和维生素补充剂对生长速率和临床病程均无影响。这些观察结果表明，鼻胃管营养补充可能会加速患有镰状细胞病且生长发育迟缓儿童的生长，并降低并发症的发生率和严重程度。
