Hospices Civils de Lyon, Service de Neurologie pédiatrique, Hôpital Femme Mère Enfant, Lyon, France.
Hospices Civils de Lyon, Epilepsie, sommeil et explorations fonctionnelles neuropédiatriques, Hôpital Femme Mère Enfant, Lyon, France.
J Atten Disord. 2020 Nov;24(13):1807-1823. doi: 10.1177/1087054717707579. Epub 2017 Jun 6.
To compare children with Neurofibromatosis type 1 and associated ADHD symptomatology (NF1 + ADHD) with children having received a diagnosis of ADHD without NF1. The idea was that performance differences in tasks of attention between these two groups would be attributable not to the ADHD symptomatology, but to NF1 alone. One group of children with NF1 + ADHD ( = 32), one group of children with ADHD ( = 31), and one group of healthy controls ( = 40) participated in a set of computerized tasks assessing intensive, selective, and executive aspects of attention. Differences were found between the two groups of patients in respect of several aspects of attention. Children with NF1 + ADHD did not always perform worse than children with ADHD. Several double dissociations can be established between the two groups of patients. ADHD symptomatology in NF1 does not contribute to all attention deficits, and ADHD cannot account for all attention impairments in NF1.
比较患有 1 型神经纤维瘤病（NF1）并伴有注意缺陷多动障碍症状（NF1+ADHD）的儿童与仅被诊断为 ADHD 而无 NF1 的儿童。我们的想法是，这两组儿童在注意力任务中的表现差异不应归因于 ADHD 症状，而应归因于 NF1 本身。一组 NF1+ADHD 患儿（=32）、一组 ADHD 患儿（=31）和一组健康对照组（=40）参与了一系列计算机化任务，评估注意力的集中、选择和执行方面。在注意力的几个方面，两组患儿之间存在差异。NF1+ADHD 患儿的表现并不总是比 ADHD 患儿差。可以在两组患儿之间建立几个双重分离。NF1 中的 ADHD 症状并非导致所有注意力缺陷的原因，而 ADHD 也不能解释 NF1 中的所有注意力损害。
