NF1 中的运动功能障碍：是由注意力缺陷引起的还是固有障碍？
Motor dysfunction in NF1: Mediated by attention deficit or inherent to the disorder?
机构信息
University Children's Hospital Tübingen, Department of Pediatric Neurology and Developmental Medicine, Hoppe-Seyler-Straße 1, 72076, Tübingen, Germany.
University Children's Hospital Tübingen, Department of Pediatric Neurology and Developmental Medicine, Hoppe-Seyler-Straße 1, 72076, Tübingen, Germany.
出版信息
Eur J Paediatr Neurol. 2018 Jan;22(1):164-169. doi: 10.1016/j.ejpn.2017.10.005. Epub 2017 Oct 20.
AIM
Attention deficit and compromised motor skills are both prevalent in Neurofibromatosis type 1 (NF1), but the relationship is unclear. We investigated motor function in children with NF1 and in children with Attention Deficit/Hyperactivity Disorder (ADHD), and explored if, in patients with NF1, attention deficit influences motor performance.
METHODS
Motor performance was measured using the Movement Assessment Battery for Children (M-ABC) in 71 children (26 with NF1 plus ADHD, 14 with NF1 without ADHD, and 31 with ADHD without NF1) aged 6-12 years.
RESULTS
There was a significant effect of group on motor performance. Both NF1 groups scored below children with ADHD without NF1. Attention performance mediated motor performance in children with ADHD without NF1, but not in children with NF1.
CONCLUSIONS
Motor function is not mediated by attention performance in children with NF1. While in ADHD, attention deficit influences motor performance, motor problems in NF1 seem to be independent from attention deficit. This argues for different pathomechanisms in these two groups of developmental disorders.
目的
注意力缺陷和运动技能受损在 1 型神经纤维瘤病（NF1）中都很常见，但两者之间的关系尚不清楚。我们研究了 NF1 患儿和注意缺陷多动障碍（ADHD）患儿的运动功能，并探讨了 NF1 患者的注意力缺陷是否会影响运动表现。
方法
采用儿童运动评估成套测验（M-ABC）对 71 名 6-12 岁的儿童（26 名 NF1 合并 ADHD、14 名 NF1 不合并 ADHD、31 名 ADHD 不合并 NF1）的运动表现进行了测量。
结果
组间运动表现存在显著差异。NF1 两组的得分均低于不合并 NF1 的 ADHD 儿童。在不合并 NF1 的 ADHD 儿童中，注意力表现对运动表现有中介作用，但在 NF1 儿童中则没有。
结论
在 NF1 儿童中，运动功能不受注意力表现的影响。在 ADHD 中，注意力缺陷会影响运动表现，而 NF1 中的运动问题似乎与注意力缺陷无关。这表明这两组发育障碍的发病机制不同。
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