Bratke Heiko, Bruserud Ingvild Særvold, Brannsether Bente, Aßmus Jörg, Bjerknes Robert, Roelants Mathieu, Júlíusson Pétur B
Department of Internal Medicine, Section of Paediatrics, Haugesund District Hospital, Haugesund, Norway.
Department of Paediatrics, Haukeland University Hospital, Bergen, Norway.
BMC Pediatr. 2017 Jun 6;17(1):138. doi: 10.1186/s12887-017-0893-x.
Research studies show conflicting results regarding the association between menarche and body weight. The purpose of the present study was to investigate if anthropometric indicators of body composition, body mass index (BMI), waist circumference (WC), triceps (TSF) and subscapular skinfold (SSF) thicknesses, were differentially associated with age at menarche in Norwegian girls.
The association between menarche and BMI, WC, TSF and SSF was investigated in 1481 girls aged 8-15.5 years, and in a subgroup of 181 girls with menarche during the 12 months prior to examination. Anthropometric measures were categorized as low (< -1SDS), average (-1 ≤ SDS ≤ +1) or high (> 1SDS), and menarche according to this classification was analysed with Kaplan-Meier curves and unadjusted and adjusted Cox regression.
The median age at menarche in the total sample was 13.1 years. In the unadjusted models, low categories of all traits were associated with later menarche, and high categories with earlier menarche. When adjusted for other covariates, earlier menarche was only related with a high BMI (Hazard Ratio 1.41, 95% confidence interval (CI) 1.07, 1.85), and later menarche with a low BMI (HR 0.53, 95%CI 0.38, 0.75) and low SSF (HR 0.54, 95%CI 0.39, 0.75). In girls with recent menarche, early menarche was significantly associated with a high BMI in the final model (HR 1.79, 95%CI 1.23, 2.62).
The timing of menarche was associated with the BMI, WC, TSF and SSF, but more strongly so with the BMI. These associations may be related to a common tempo of growth, as the mean age at menarche has remained stable during the last decades during a time period while the prevalence of overweight and obesity has increased significantly.
关于初潮与体重之间的关联，研究结果相互矛盾。本研究的目的是调查身体成分的人体测量指标，即体重指数（BMI）、腰围（WC）、肱三头肌皮褶厚度（TSF）和肩胛下皮褶厚度（SSF），是否与挪威女孩的初潮年龄存在差异关联。
对1481名8至15.5岁的女孩进行了初潮与BMI、WC、TSF和SSF之间的关联研究，并对其中181名在检查前12个月内初潮的女孩亚组进行了研究。人体测量指标分为低（<-1标准差）、平均（-1≤标准差≤+1）或高（>1标准差），并根据此分类用Kaplan-Meier曲线以及未调整和调整后的Cox回归分析初潮情况。
总样本的初潮中位年龄为13.1岁。在未调整模型中，所有特征的低类别与初潮较晚相关，高类别与初潮较早相关。在调整其他协变量后，初潮较早仅与高BMI相关（风险比1.41，95%置信区间（CI）1.07，1.85），初潮较晚与低BMI（HR 0.53，95%CI 0.38，0.75）和低SSF（HR 0.54，95%CI 0.39，0.75）相关。在近期初潮的女孩中，最终模型显示初潮较早与高BMI显著相关（HR 1.79，95%CI 1.23，2.62）。
初潮时间与BMI、WC、TSF和SSF相关，但与BMI的相关性更强。这些关联可能与共同的生长节奏有关，因为在过去几十年中，初潮的平均年龄保持稳定，而超重和肥胖的患病率却显著增加。
