泽替多林可阻断大鼠黑质中的多巴胺自身受体。

Zetidoline blocks dopamine autoreceptors in the rat substantia nigra.

作者信息

Harris N C, Pinnock R D, Woodruff G N

出版信息

Neuropharmacology. 1985 Jan;24(1):33-6. doi: 10.1016/0028-3908(85)90092-9.

Abstract

Zetidoline, applied microiontophoretically onto neurones in the substantia nigra, zona compacta of anaesthetized rats, reversibly blocked the depressant effect of iontophoretically-applied dopamine. The inhibitory actions of gamma-aminobutyric acid (GABA) and glycine and the excitatory action of glutamate were unaffected by the antagonist. Zetidoline applied by bath perfusion, was similarly an antagonist of the inhibitory effect of bath applications of dopamine on neurones in the zona compacta of slices of substantia nigra; the pA2 for zetidoline in this preparation was 7.0.

摘要

将泽替多林通过微离子电泳法施加于麻醉大鼠黑质致密部的神经元上，可可逆地阻断通过离子电泳法施加多巴胺的抑制作用。γ-氨基丁酸（GABA）、甘氨酸的抑制作用以及谷氨酸的兴奋作用均不受该拮抗剂的影响。通过浴式灌流施加泽替多林，同样是浴式施加多巴胺对黑质切片致密部神经元抑制作用的拮抗剂；在此制剂中泽替多林的pA2为7.0。