Bartholome Odile, Van den Ackerveken Priscilla, Sánchez Gil Judit, de la Brassinne Bonardeaux Orianne, Leprince Pierre, Franzen Rachelle, Rogister Bernard
Laboratory of Nervous System Disorders and Therapy, GIGA-Neurosciences, University of LiègeLiège, Belgium.
Department of Neurology, Centre Hospitalier Universitaire de Liège (CHU), University of LiègeLiège, Belgium.
Front Mol Neurosci. 2017 May 22;10:148. doi: 10.3389/fnmol.2017.00148. eCollection 2017.
Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer's or Parkinson's disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.
突触囊泡蛋白2（SV2）于80年代初被发现，但直到明确证明SV2A是来自吡拉西坦家族的有效抗癫痫药物的靶点后，才激发了人们对其在大脑中作用的深入理解。关于SV2蛋白已经提出了许多功能，包括离子或神经递质运输或突触囊泡的启动。此外，最近的几项研究强调了SV2与不同神经元疾病之间的联系，如癫痫、精神分裂症（SCZ）、阿尔茨海默病或帕金森病。在这篇综述文章中，我们将总结目前关于SV2A功能及其在各种脑部疾病病理生理学中潜在作用的知识。
