Wafer Rebecca, Tandon Panna, Minchin James E N
BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Front Endocrinol (Lausanne). 2017 May 22;8:102. doi: 10.3389/fendo.2017.00102. eCollection 2017.
The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and amenability to high-resolution imaging of cell dynamics within live animals. However, zebrafish adipose research is at a nascent stage and many gaps exist in our understanding of zebrafish adipose physiology and metabolism. By contrast, adipose research within other, closely related, teleost species has a rich and extensive history, owing to the economic importance of these fish as a food source. Here, we compare and contrast knowledge on peroxisome proliferator-activated receptor gamma (PPARG)-mediated adipogenesis derived from both biomedical and aquaculture literatures. We first concentrate on the biomedical literature to (i) briefly review PPARG-mediated adipogenesis in mammals, before (ii) reviewing Pparg-mediated adipogenesis in zebrafish. Finally, we (iii) mine the aquaculture literature to compare and contrast Pparg-mediated adipogenesis in aquaculturally relevant teleosts. Our goal is to highlight evolutionary similarities and differences in adipose biology that will inform our understanding of the role of adipose tissue in obesity and related disease.
热带淡水斑马鱼最近已成为研究脂肪组织生物学和肥胖相关疾病的一种有价值的模式生物。斑马鱼模型系统的优势在于其丰富的基因突变体、转基因工具，以及对活体动物体内细胞动态进行高分辨率成像的便利性。然而，斑马鱼脂肪研究尚处于起步阶段，我们对斑马鱼脂肪生理学和代谢的理解存在许多空白。相比之下，由于这些鱼类作为食物来源具有经济重要性，其他密切相关的硬骨鱼类的脂肪研究有着丰富而广泛的历史。在这里，我们比较和对比了来自生物医学和水产养殖文献中关于过氧化物酶体增殖物激活受体γ（PPARG）介导的脂肪生成的知识。我们首先专注于生物医学文献，（i）简要回顾哺乳动物中PPARG介导的脂肪生成，然后（ii）回顾斑马鱼中Pparg介导的脂肪生成。最后，我们（iii）挖掘水产养殖文献，以比较和对比水产养殖相关硬骨鱼类中Pparg介导的脂肪生成。我们的目标是突出脂肪生物学中的进化异同，这将有助于我们理解脂肪组织在肥胖及相关疾病中的作用。
