Luo Liping, Liu Meilian
Department of Metabolism and EndocrinologyMetabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Metabolism and EndocrinologyMetabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
J Endocrinol. 2016 Dec;231(3):R77-R99. doi: 10.1530/JOE-16-0211.
Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity. Therefore, adipose tissue dysfunction plays a prominent role in the development of obesity and its related disorders such as insulin resistance, cardiovascular disease, diabetes, depression and cancer. In this review, we will summarize the recent findings of adipose tissue in the control of metabolism, focusing on its endocrine and thermogenic function.
脂肪组织通过其在器官和全身水平的微妙功能，在调节全身能量和葡萄糖稳态中发挥核心作用。一方面，脂肪组织以脂质形式储存能量，并控制体内脂质的动员和分布。另一方面，脂肪组织作为一个内分泌器官，产生许多生物活性因子，如脂肪因子，这些因子与其他器官相互作用并调节一系列代谢途径。此外，棕色和米色脂肪组织通过以热量形式消耗能量来燃烧脂质以维持正常体温，并且已被视为对抗肥胖的一种新方法。因此，脂肪组织功能障碍在肥胖及其相关疾病如胰岛素抵抗、心血管疾病、糖尿病、抑郁症和癌症的发展中起着重要作用。在这篇综述中，我们将总结脂肪组织在代谢控制方面的最新发现，重点关注其内分泌和产热功能。
