Duggan A W
Philos Trans R Soc Lond B Biol Sci. 1985 Feb 19;308(1136):375-91. doi: 10.1098/rstb.1985.0038.
In the cat there is no convincing evidence that a particular compound mediates a supraspinal control of spinal transmission of nociceptive information. There is good evidence that opioid peptides are released segmentally in response to nociceptive input to the spinal cord and that this acts to inhibit motoneurons and to reduce transmission of nociceptive information to supraspinal areas. In the cat there is no evidence that stimulation at supraspinal sites producing analgesia results in a spinal release of opioid peptides. In the rat evidence for the latter has been obtained but there are no data from other species. Tonically present supraspinal inhibition of spinal transmission of nociceptive information in the cat does not involve opioid peptides. Indirect evidence favours a role for 5-hydroxytryptamine and noradrenaline in supraspinal control of spinal processing of nociceptive transmission. Peripheral antagonists of 5-HT have reduced spinal inhibition from stimulation at supraspinal sites but the site of action is unknown. Progress with noradrenaline involvement has been hindered by lack of a suitable antagonist. Although the amino acids, glycine and GABA are involved in segmental inhibition of transmission of nociceptive information, no convincing evidence has indicated their involvement in supraspinal controls.
在猫身上，没有令人信服的证据表明某种特定化合物介导了脊髓上对伤害性信息脊髓传递的控制。有充分证据表明，阿片肽会在脊髓对伤害性输入做出反应时分节段释放，并且这会抑制运动神经元，并减少伤害性信息向脊髓上区域的传递。在猫身上，没有证据表明脊髓上部位产生镇痛的刺激会导致脊髓释放阿片肽。在大鼠身上已获得了关于后者的证据，但没有来自其他物种的数据。猫身上持续存在的脊髓上对伤害性信息脊髓传递的抑制并不涉及阿片肽。间接证据支持5-羟色胺和去甲肾上腺素在脊髓上对伤害性传递脊髓处理的控制中发挥作用。5-羟色胺的外周拮抗剂减少了脊髓上部位刺激引起的脊髓抑制，但作用部位尚不清楚。去甲肾上腺素参与方面的研究进展因缺乏合适的拮抗剂而受阻。尽管氨基酸、甘氨酸和γ-氨基丁酸参与了伤害性信息传递的节段性抑制，但没有令人信服的证据表明它们参与脊髓上的控制。
