Tosato Giovanna
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 4124, Bethesda, MD, 20892, USA.
Cell Mol Life Sci. 2017 Sep;74(18):3377-3394. doi: 10.1007/s00018-017-2566-1. Epub 2017 Jun 6.
Hematopoietic stem and progenitor cells reside predominantly in the bone marrow. They supply billions of mature blood cells every day during life through maturation into multilineage progenitors and self-renewal. Newly produced mature cells serve to replenish the pool of circulating blood cells at the end of their life-span. These mature blood cells and a few hematopoietic progenitors normally exit the bone marrow through the sinusoidal vessels, a specialized venous vascular system that spreads throughout the bone marrow. Many signals regulate the coordinated mobilization of hematopoietic cells from the bone marrow to the circulation. In this review, we present recent advances on hematopoiesis and hematopoietic cell mobilization with a focus on the role of Ephrin ligands and their Eph receptors. These constitute a large family of transmembrane ligands and receptors that play critical roles in development and postnatally. New insights point to distinct roles of ephrin and Eph in different aspects of hematopoiesis.
造血干细胞和祖细胞主要存在于骨髓中。在生命过程中，它们每天通过成熟为多谱系祖细胞和自我更新产生数十亿个成熟血细胞。新产生的成熟细胞在其寿命结束时用于补充循环血细胞池。这些成熟血细胞和一些造血祖细胞通常通过窦状血管离开骨髓，窦状血管是一种遍布骨髓的特殊静脉血管系统。许多信号调节造血细胞从骨髓到循环的协调动员。在这篇综述中，我们介绍了造血和造血细胞动员方面的最新进展，重点是 Ephrin 配体及其 Eph 受体的作用。它们构成了一个在发育和出生后起关键作用的跨膜配体和受体大家族。新的见解指出了 Ephrin 和 Eph 在造血不同方面的不同作用。
