Nguyen Thao M, Arthur Agnieszka, Gronthos Stan
Int J Hematol. 2016 Feb;103(2):145-54. doi: 10.1007/s12185-015-1886-x.
Bone marrow mesenchymal stromal/stem cells(BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrinligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrintargeted therapeutic strategies that are currently being pursued or various hematotological malignancies.
骨髓间充质基质/干细胞（BMSC）是造血干细胞微环境的基本调节元件；然而，介导BMSC对造血支持作用的分子信号仍知之甚少。最近的研究表明，BMSC和造血干/祖细胞差异表达Eph细胞表面酪氨酸激酶受体及其ephrin配体。Eph/ephrin相互作用被认为介导BMSC与不同造血细胞群体之间的相互作用，以影响细胞发育、迁移和功能。本文综述了Eph/ephrin相互作用在调节BMSC与造血干/祖细胞通讯中的作用，并讨论了目前正在探索的针对各种血液系统恶性肿瘤的Eph/ephrin靶向治疗策略。
