Costello Benedict T, Springer Fabian, Hare James L, Gerche Andre La, Iles Leah, Ellims Andris H, Schmitt Benjamin, Taylor Andrew J
The Alfred Hospital, Melbourne, Australia.
Baker Heart and Diabetes Institute, Melbourne, Australia.
Int J Cardiovasc Imaging. 2017 Oct;33(10):1551-1560. doi: 10.1007/s10554-017-1134-y. Epub 2017 Jun 6.
Cardiac Magnetic Resonance derived T1 mapping parameters are a non-invasive method of estimating diffuse myocardial fibrosis. This study aims to to determine the native T1 time, post contrast T1 time and extracellular volume (ECV) derived from T1 mapping and to evaluate the ability of T1 mapping techniques to discriminate healthy myocardium from dilated cardiomyopathy. Seventy-nine participants underwent cardiac magnetic resonance imaging at the Baker Heart and Diabetes Institute, Melbourne, Australia. Fifty-seven healthy volunteers and twenty-two patients with Dilated cardiomyopathy were included in the study. Each participant had T1 mapping sequences performed at 3 T in the mid short axis slice-both SASHA and ShMOLLI T1 mapping were performed. Native T1, post contrast T1 and ECV values were compared in health and dilated cardiomyopathy. Native T1, post contrast T1 and ECV differed significantly between SASHA and ShMOLLI techniques (P < 0.001). All T1 parameters had similar ability to discriminate normal from abnormal myocardium (ROC AUC 0.691 to 0.830). Converting T1 values to Z scores significantly improved the agreement between SASHA and ShMOLLI techniques, particularly for post contrast T1 (ICC 0.19 to 0.895) and ECV (ICC 0.461 to 0.880). T1 mapping values from SASHA and ShMOLLI show strong correlation for post contrast measures, though with a consistent offset for all measures in health and dilated cardiomyopathy. All measures obtained using SASHA and ShMOLLI allow good discrimination between dilated cardiomyopathy and normal myocardium.
心脏磁共振成像衍生的T1映射参数是一种估计弥漫性心肌纤维化的非侵入性方法。本研究旨在确定从T1映射得出的固有T1时间、对比剂后T1时间和细胞外容积（ECV），并评估T1映射技术区分健康心肌与扩张型心肌病的能力。79名参与者在澳大利亚墨尔本的贝克心脏与糖尿病研究所接受了心脏磁共振成像检查。研究纳入了57名健康志愿者和22名扩张型心肌病患者。每位参与者在3T磁场下的短轴中部层面进行了T1映射序列检查——同时进行了SASHA和ShMOLLI T1映射。比较了健康组和扩张型心肌病组的固有T1、对比剂后T1和ECV值。SASHA和ShMOLLI技术之间的固有T1、对比剂后T1和ECV存在显著差异（P < 0.001）。所有T1参数区分正常心肌与异常心肌的能力相似（ROC曲线下面积为0.691至0.830）。将T1值转换为Z分数显著改善了SASHA和ShMOLLI技术之间的一致性，尤其是对比剂后T1（组内相关系数为0.19至0.895）和ECV（组内相关系数为0.461至0.880）。SASHA和ShMOLLI的T1映射值在对比剂后测量中显示出很强的相关性，不过在健康组和扩张型心肌病组中所有测量值都有一致的偏移。使用SASHA和ShMOLLI获得的所有测量值都能很好地区分扩张型心肌病和正常心肌。
