Cancer & Palliative Care Services, Toowoomba Hospital, Toowoomba, Australia.
School of Medicine, University of Queensland, Toowoomba Hospital, Toowoomba, Australia.
Future Oncol. 2017 Jun;13(15):1311-1322. doi: 10.2217/fon-2017-0033. Epub 2017 Jun 7.
To identify cancer drugs amenable to strategies for reducing expenditure and avoiding drug wastage.
Information was sourced from product information in 20 countries on parenteral cytotoxic agents, and cancer and noncancer monoclonal antibodies. Data were collected on vial sizes, overage, stability and presentation forms.
Vial size availability varied significantly between countries, with often only single vial sizes for numerous medications. Overage was poorly reported. Stability data were inconsistent and variable between countries, with most drugs only having a 24 h expiry. Three cancer-indicated monoclonal antibodies, thought suitable for prefilled syringe administration, were only available as vials.
Many expensive cancer drugs are suitable for global cost-reduction strategies. Collaboration is vital to affecting change and reducing expenditure.
确定可采取降低支出和避免药物浪费策略的癌症药物。
从 20 个国家的细胞毒性药物、癌症和非癌症单克隆抗体的产品信息中获取信息。收集小瓶大小、余量、稳定性和制剂形式的数据。
各国小瓶大小的供应情况差异很大，许多药物通常只有单一的小瓶大小。余量报告不佳。稳定性数据在各国之间不一致且多变，大多数药物的有效期只有 24 小时。三种被认为适合预填充注射器给药的癌症单克隆抗体，仅作为小瓶供应。
许多昂贵的癌症药物适合全球成本降低策略。协作对于改变现状和降低成本至关重要。
