School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China.
Biomater Sci. 2017 Jun 27;5(7):1236-1240. doi: 10.1039/c7bm00221a.
Curved corannulene (Cor) can produce reactive oxygen species (ROS) in a controlled manner due to the large dipole moment. However, the poor aqueous solubility of Cor necessitates the employment of solubilization vehicles. This work revealed that PEGylation was less efficient than the cyclodextrin complexation regarding ROS production.
由于大偶极矩的存在，弯曲的corannulene（Cor）可以以可控的方式产生活性氧物质（ROS）。然而，Cor 的水溶性差，需要使用增溶剂。这项工作表明，PEG 化在产生 ROS 方面不如环糊精络合有效。
