Kaldany R R, Nambu J R, Scheller R H
Annu Rev Neurosci. 1985;8:431-55. doi: 10.1146/annurev.ne.08.030185.002243.
Extensive electrophysiological experiments on Aplysia neurons have resulted in an understanding of simple behaviors in terms of the activities of a single identified neurons. Beginning with the work of Kupfermann & Kandel, neuropeptides in Aplysia have become increasingly implicated as chemical agents that control or affect behavior. Several neuropeptides have been isolated and characterized; recently, the genes that code for several of these neuropeptides have been isolated. Studies of neuropeptide gene expression and the behaviors affected thereby have been bridged in the egg-laying hormone neuroendocrine system. The role of polyproteins in coordinating complex, fixed-action patterns is beginning to emerge. The continued investigation of this neuroendocrine system, and the other cell-specific polyproteins that have been characterized more recently, promises to yield further insights into the roles of neuropeptides in governing behavior.
对海兔神经元进行的大量电生理实验，使人们能够根据单个已识别神经元的活动来理解简单行为。从库普费尔曼和坎德尔的工作开始，海兔中的神经肽越来越被认为是控制或影响行为的化学介质。几种神经肽已被分离和鉴定；最近，编码其中几种神经肽的基因也已被分离出来。在产卵激素神经内分泌系统中，对神经肽基因表达及其所影响行为的研究已建立起联系。多蛋白在协调复杂的固定动作模式中的作用正开始显现出来。对这个神经内分泌系统以及最近才被鉴定的其他细胞特异性多蛋白的持续研究，有望进一步深入了解神经肽在支配行为中的作用。
