钴(III)催化马来酰亚胺和马来酸酯对（杂）芳基的 C-H 烷基化反应。
C-H Alkylations of (Hetero)Arenes by Maleimides and Maleate Esters through Cobalt(III) Catalysis.
机构信息
School of Pharmaceutical Science, Jiangnan University , Lihu Road 1800, 214122 Wuxi, P. R. China.
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen , Tammannstrasse 2, 37077 Göttingen, Germany.
出版信息
Org Lett. 2017 Jun 16;19(12):3315-3318. doi: 10.1021/acs.orglett.7b01480. Epub 2017 Jun 7.
Efficient cobalt(III)-catalyzed (hetero)aryl and alkenyl C-H hydroarylations of maleimides and maleate esters have been achieved under remarkably mild reaction conditions. Thus, the versatile cobalt(III) catalyst [Cp*CoI(CO)] showed excellent atom-and step-economy as well as high chemo- and site-selectivity providing expedient access to pharmacologically useful succinimides with wide functional group tolerance.
高效钴(III)催化马来酰亚胺和马来酸酯的（杂）芳基和烯基 C-H 芳基化反应在非常温和的反应条件下得以实现。因此，多功能钴(III)催化剂 [Cp*CoI(CO)] 表现出出色的原子经济性和步骤经济性以及高的化学选择性和位点选择性，为具有广泛官能团耐受性的具有药理用途的琥珀酰亚胺提供了便捷的合成途径。
Zotero 插件