Shindler J, Schachter M, Brincat S, Parkes J D
Br Med J (Clin Res Ed). 1985 Apr 20;290(6476):1167-70. doi: 10.1136/bmj.290.6476.1167.
Twenty patients with the narcoleptic syndrome were treated separately with dexamphetamine sulphate tablets 10 and 30 mg, Dexedrine Spansules 10 mg, mazindol 4 mg, and fencamfamin hydrochloride 60 mg daily. Each drug was given for four weeks and the effects compared. In these dosages the reported frequency of attacks of narcolepsy was roughly halved with each treatment, dexamphetamine 30 mg daily being only slightly more potent than 10 mg. The subjective effects of Dexedrine tablets and Spansules could not be distinguished by most patients. Effects on mood, alertness, and sympathomimetic side effects were largely inseparable with all these drugs, but a decrease in appetite was not reported by patients with narcolepsy.
20例发作性睡病综合征患者分别接受每日10毫克和30毫克硫酸右旋苯丙胺片、10毫克长效右旋苯丙胺胶囊、4毫克马吲哚以及60毫克盐酸芬坎法明治疗。每种药物给药四周并比较疗效。在这些剂量下，每种治疗使发作性睡病的发作频率大致减半，每日30毫克右旋苯丙胺的效力仅略高于10毫克。大多数患者无法区分长效右旋苯丙胺片和胶囊的主观效果。所有这些药物对情绪、警觉性和拟交感神经副作用的影响在很大程度上难以区分，但发作性睡病患者未报告食欲下降。
