Franc Aleš, Kurhajec Slavomir, Pavloková Sylvie, Sabadková Dana, Muselík Jan
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Acta Pharm. 2017 Jun 27;67(2):187-202. doi: 10.1515/acph-2017-0019.
The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH).
本研究的目的是找出含有最高量（山茱萸）干果实的最佳片剂配方。研究了两种不同类型的微晶纤维素（微晶纤维素PH 101和微晶纤维素PH 200）的三种不同浓度（12.5%、25%和50%）以及三种不同的压制压力（20兆帕、60兆帕和100兆帕）对片剂混合物和片剂物理性质的影响。发现在100兆帕压力下压制的含有50%微晶纤维素PH 101的片剂具有最佳物理性质。即使在加速稳定性条件（6个月，40℃和75%相对湿度）下储存后，这种配方和压制压力的组合也能得到稳定的片剂。
