Liu Xing-Ya, Wang Hong-Jing, Xu Pan, Chen Jing, Pan Hai-Ying, Liu Ya
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Jul;47(4):512-515.
To investigate the expressions of Livin and phosphate and tension homology deleted on chromsome ten (PTEN) protein in the cancerous tissues of ovary endometriosis.
Immunohistochemistry EliVision was used to examine the expressions of Livin and PETN protein in 19 samples of ovary endometriosis cancerous tissues, 30 samples of ovary endometriosis tissues and 30 samples of ovarian benign tumor tissues.
The positive expression rate of Livin in ovary endometriosis cancerous tissues (68%) was obviously higher than that in ovary endometriosis tissues (36%) and benign tumor tissues (13%)( <0.05). The positive expression rate of PTEN in ovary endometriosis cancerous tissues (16%) was obviously lower than that in ovary endometriosis tissues (65%) and benign tumor tissues (80%)( <0.01). There was no correlations between positive expressions of Livin and age, clinical stage, grading, histological type and lymphatic metastasis of ovary endometriosis cancer ( >0.05), the same result was also found for PTEN. Livin and PTEN expression presented an obviously negative correlation in ovary endometriosis cancer ( =-0.559, =0.001).
Up-regulation of Livin expression and down-regulation of PTEN may be involved in the occurrence and development of ovary endometriosis cancerization.
探讨Livin及10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）蛋白在卵巢子宫内膜异位症癌组织中的表达情况。
采用免疫组织化学EliVision法检测19例卵巢子宫内膜异位症癌组织、30例卵巢子宫内膜异位症组织及30例卵巢良性肿瘤组织中Livin和PTEN蛋白的表达。
Livin在卵巢子宫内膜异位症癌组织中的阳性表达率（68%）明显高于卵巢子宫内膜异位症组织（36%）及良性肿瘤组织（13%）（P<0.05）。PTEN在卵巢子宫内膜异位症癌组织中的阳性表达率（16%）明显低于卵巢子宫内膜异位症组织（65%）及良性肿瘤组织（80%）（P<0.01）。卵巢子宫内膜异位症癌中Livin的阳性表达与年龄、临床分期、分级、组织学类型及淋巴转移均无相关性（P>0.05），PTEN亦如此。在卵巢子宫内膜异位症癌中Livin与PTEN表达呈明显负相关（r=-0.559，P=0.001）。
Livin表达上调及PTEN表达下调可能参与卵巢子宫内膜异位症癌变的发生与发展。
Zotero 插件