Liao Xue-Lian, Xie Zhi-Chao, Kang Yan
Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Jul;47(4):570-573.
Sepsis is a critical clinical syndrome which keep puzzling the medical profession for many years. Recently, the results from several large-scale trials challenged the necessity of early goal directed therapy (EGDT) in surviving sepsis bundle, These trials were not opposed to EGDT but bring new concept that it is essential to utilize therapy with multiple monitoring measures in order to minimize injury while guarantee the safety . Deeper understanding in the pathogenesis of sepsis gives rise to the update of its definition based on vital organ dysfunction. The importance of dynamic monitoring in defining sepsis also need to be emphasized. Developing more effective monitoring measures could provide better treatments, thus improve the prognosis of septic patients.
脓毒症是一种严重的临床综合征，多年来一直困扰着医学界。最近，几项大规模试验的结果对脓毒症拯救集束治疗中早期目标导向治疗（EGDT）的必要性提出了挑战。这些试验并非反对EGDT，而是带来了新的概念，即必须采用多种监测措施进行治疗，以便在保证安全的同时将损伤降至最低。对脓毒症发病机制的更深入理解促使基于重要器官功能障碍对其定义进行更新。还需要强调动态监测在定义脓毒症中的重要性。开发更有效的监测措施可以提供更好的治疗方法，从而改善脓毒症患者的预后。
