细胞色素P450氧化还原酶的两种变体对西班牙人群中醋硝香豆素稳定剂量的影响。
Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population.
作者信息
Tong Hoi Y, Borobia Alberto M, Martínez Ávila José Carlos, Lubomirov Rubin, Muñoz Mario, Blanco Bañares María J, Hernández Rafael, Fernández Capitán Carmen, Ramírez Elena, Frías Jesús, Carcas Antonio J
机构信息
Clinical Pharmacology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.
Pharmacology Department, School of Medicine, Autonomous University of Madrid, IdiPAZ, Madrid, Spain.
出版信息
Pharmacogenomics. 2017 Jun;18(8):797-805. doi: 10.2217/pgs-2017-0021. Epub 2017 Jun 8.
AIM
To evaluate the influence of two variants of P450 oxidoreductase (POR), rs2868177 and POR*28, on the stable dosage of acenocoumarol.
PATIENTS & METHODS: For this observational, cross-sectional study, patients were undergone stable anticoagulant treatment with acenocoumarol. Univariate and multiple regression analyses were performed to assess the influence of POR polymorphisms.
RESULTS
About 340 patients were enrolled. Multiple regression had a coefficient of determination (R) of 51.5% and an Akaike information criterion of 234.22. The inclusion of POR28 polymorphisms increased the R to 52.0% and reduced the Akaike information criteria to 230.58. The POR28 heterozygote showed statistical significance in the algorithm.
CONCLUSION
The POR*28 heterozygote appears to be associated with the stable dose of acenocoumarol, but its clinical contribution to the prediction of the dosing of this drug is minimal.
目的
评估细胞色素P450氧化还原酶（POR）的两种变体rs2868177和POR*28对醋硝香豆素稳定剂量的影响。
患者与方法
在这项观察性横断面研究中，患者接受了醋硝香豆素的稳定抗凝治疗。进行单因素和多因素回归分析以评估POR基因多态性的影响。
结果
纳入约340例患者。多因素回归的决定系数（R）为51.5%，赤池信息准则为234.22。纳入POR28基因多态性后，R增加到52.0%，赤池信息准则降低到230.58。POR28杂合子在算法中具有统计学意义。
结论
POR*28杂合子似乎与醋硝香豆素的稳定剂量有关，但其对该药物剂量预测的临床贡献极小。
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