Ogawa N, Namiki M, Kusunoki T, Fujii S
Int J Clin Pharmacol Ther Toxicol. 1985 Feb;23(2):109-11.
One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer. Healing of ulcers was confirmed by endoscopic examinations. For evaluation of the treatment effect, the "life table" method was applied to the analysis of the data. The results revealed that ulcer healing with the combination was faster by two weeks than that with alprazolam or gefarnate alone. The difference did not reach the statistical significance in all the subjects who fulfilled the entry criteria. There was, however, a statistical difference between treatments in the patients having manifest psychic symptoms such as anxiety, insomnia and depressive mood (p less than 0.05 by generalized Kruskal-Wallis test and p less than 0.1 by Logrank test). The rate of patients who had psychic symptoms before entry and had not been cured of ulcers at the 4th week of treatment was 61% on the combination treatment as compared to 96% on the gefarnate treatment and 93% on the alprazolam treatment.
139例经内镜确诊为消化性溃疡（胃溃疡和十二指肠溃疡）的患者，参与了一项关于阿普唑仑（1.2毫克/天）、吉法酯（300毫克/天）及其联合用药治疗消化性溃疡的双盲对比评估。溃疡愈合情况通过内镜检查确定。为评估治疗效果，采用“生命表”方法对数据进行分析。结果显示，联合用药组溃疡愈合时间比单独使用阿普唑仑或吉法酯快两周。在所有符合入选标准的受试者中，差异未达到统计学意义。然而，在有明显精神症状如焦虑、失眠和抑郁情绪的患者中，治疗组之间存在统计学差异（广义Kruskal-Wallis检验p值小于0.05，对数秩检验p值小于0.1）。治疗第4周时，治疗前有精神症状且溃疡未愈合的患者，联合治疗组的比例为61%，而吉法酯治疗组为96%，阿普唑仑治疗组为93%。
