Cohn J B, Wilcox C S
J Clin Psychiatry. 1986 Aug;47(8):409-12.
Buspirone was compared to alprazolam and lorazepam in the treatment of generalized anxiety disorder in a 4-week, double-blind study of 60 patients. All three medications were effective and similar in producing significant reductions in anxiety as assessed by standardized anxiety rating scales and by global evaluations of patients by physicians. There were significant differences in drowsiness, lethargy, and/or fatigue: fewer patients in the buspirone group than in the alprazolam group (16% vs. 60%, respectively; p less than .01) or the lorazepam group (16% vs. 65%, respectively; p less than .0003) experienced these undesirable side effects. This demonstration of similar effectiveness and superior safety would favor buspirone in the treatment of generalized anxiety disorder.
在一项为期4周、针对60名患者的双盲研究中，将丁螺环酮与阿普唑仑和劳拉西泮用于治疗广泛性焦虑症进行了比较。通过标准化焦虑评定量表以及医生对患者的整体评估发现，这三种药物均有效，且在显著减轻焦虑方面效果相似。在嗜睡、无精打采和/或疲劳方面存在显著差异：丁螺环酮组出现这些不良副作用的患者少于阿普唑仑组（分别为16%对60%；p<0.01）或劳拉西泮组（分别为16%对65%；p<0.0003）。这种相似有效性和更高安全性的表现表明，丁螺环酮在治疗广泛性焦虑症方面更具优势。
