抗精神病药物治疗中的患者间差异。
Interpatient variations in antipsychotic therapy.
作者信息
McIntyre I M, Gershon S
出版信息
J Clin Psychiatry. 1985 May;46(5 Pt 2):3-5.
PMID:2859279
Abstract
There is wide interpatient variability not only in therapeutic response to a given dose of antipsychotic drug but also in steady-state plasma levels and the presence and degree of unwanted pharmacologic effects. Such variations have been attributed to individual metabolism, pharmacologic differences, and age--all of which may need careful consideration in prescribing an appropriate dosage regimen for a given patient.
摘要
患者之间不仅在对给定剂量抗精神病药物的治疗反应上存在很大差异，而且在稳态血浆水平以及不良药理作用的存在和程度方面也存在差异。这些差异归因于个体代谢、药理学差异和年龄——在为特定患者制定合适的给药方案时，所有这些因素都可能需要仔细考虑。
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