用于预防抗精神病药物所致肌张力障碍反应的抗胆碱能药物：一项前瞻性研究。
Anticholinergic agents for prophylaxis of neuroleptic-induced dystonic reactions: a prospective study.
作者信息
Sramek J J, Simpson G M, Morrison R L, Heiser J F
出版信息
J Clin Psychiatry. 1986 Jun;47(6):305-9.
The development of acute dystonic reactions was monitored in 202 acute psychiatric patients during initial hospitalization and treatment with various neuroleptic drugs in a prospective study. Data were analyzed to determine the effect of anticholinergic prophylaxis, age, sex, and type and dosage of neuroleptic on the incidence of dystonic reactions. Nearly 90% of dystonic reactions occurred by the third day of treatment. The overall trend favored the prophylactic use of antiparkinsonian drugs with all neuroleptics, and the effect of this prophylaxis with haloperidol was statistically significant. Because anticholinergic prophylaxis was used more often when larger dosages of neuroleptics were prescribed, an added effect in the observed trend for fewer dystonic reactions is suggested.
在一项前瞻性研究中，对202例急性精神病患者在初次住院并使用各种抗精神病药物治疗期间急性肌张力障碍反应的发生情况进行了监测。对数据进行分析，以确定抗胆碱能预防措施、年龄、性别、抗精神病药物的类型和剂量对肌张力障碍反应发生率的影响。近90%的肌张力障碍反应发生在治疗的第三天。总体趋势支持对所有抗精神病药物预防性使用抗帕金森病药物，且这种预防措施对氟哌啶醇的效果具有统计学意义。由于在开具较大剂量抗精神病药物时更常使用抗胆碱能预防措施，这表明在观察到的肌张力障碍反应较少的趋势中存在额外的效果。
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