Department of Epidemiology, College of Public Health and Health Professions, University of Florida, PO Box 100231, CTRB 4233, Gainesville, FL, 32610, USA.
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
AIDS Behav. 2018 May;22(5):1411-1422. doi: 10.1007/s10461-017-1822-6.
To describe patterns of depressive symptoms across 10-years by HIV status and to determine the associations between depressive symptom patterns, HIV status, and clinical profiles of persons living with HIV from the Multicenter AIDS Cohort Study (N = 980) and Women's Interagency HIV Study (N = 1744). Group-based trajectory models were used to identify depressive symptoms patterns between 2004 and 2013. Multinomial logistic regressions were conducted to determine associations of depression risk patterns. A 3-group model emerged among HIV-negative women (low: 58%; moderate: 31%; severe: 11%); 5-groups emerged among HIV-positive women (low: 28%; moderate: 31%; high: 25%; decreased: 7%; severe: 9%). A 4-group model emerged among HIV-negative (low: 52%; moderate: 15%; high: 23%; severe: 10%) and HIV-positive men (low: 34%; moderate: 34%; high: 22%; severe: 10%). HIV+ women had higher odds for moderate (adjusted odds ratio [AOR] 2.10, 95% CI 1.63-2.70) and severe (AOR 1.96, 95% CI 1.33-2.91) depression risk groups, compared to low depression risk. HIV+ men had higher odds for moderate depression risk (AOR 3.23, 95% CI 2.22-4.69), compared to low risk. The Framingham Risk Score, ART use, and unsuppressed viral load were associated with depressive symptom patterns. Clinicians should consider the impact that depressive symptoms may have on HIV prognosis and clinical indicators of comorbid illnesses.
描述 10 年来按 HIV 状况划分的抑郁症状模式，并确定多中心艾滋病队列研究（N=980）和妇女机构间艾滋病毒研究（N=1744）中艾滋病毒感染者的抑郁症状模式、HIV 状况和临床特征之间的关联。使用基于群组的轨迹模型来确定 2004 年至 2013 年间的抑郁症状模式。进行多分类逻辑回归以确定抑郁风险模式的关联。在 HIV 阴性女性中出现了 3 组模型（低：58%；中度：31%；严重：11%）；在 HIV 阳性女性中出现了 5 组模型（低：28%；中度：31%；高：25%；减少：7%；严重：9%）。在 HIV 阴性（低：52%；中度：15%；高：23%；严重：10%）和 HIV 阳性男性（低：34%；中度：34%；高：22%；严重：10%）中出现了 4 组模型。与低风险相比，HIV+女性发生中度（调整后的优势比[OR]2.10，95%置信区间[CI]1.63-2.70）和重度（OR 1.96，95%CI 1.33-2.91）抑郁风险的几率更高。与低风险相比，HIV+男性发生中度抑郁风险的几率更高（OR 3.23，95%CI 2.22-4.69）。Framingham 风险评分、ART 使用和未抑制的病毒载量与抑郁症状模式相关。临床医生应考虑抑郁症状对 HIV 预后和合并症临床指标的影响。
