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艾滋病毒心理健康研究中的公平性:行动呼吁。

Equity in HIV mental health research: a call to action.

机构信息

Edinburgh Neuroscience, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.

Family Centre for Research with Ubuntu (FAMCRU), Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.

出版信息

Mol Psychiatry. 2022 Dec;27(12):4824-4828. doi: 10.1038/s41380-022-01748-8. Epub 2022 Sep 2.

Abstract

The brain remains a key reservoir of latent HIV infection, and people living with HIV (PLWH) face a high risk for cognitive impairment and psychiatric disorders. Although the burden of HIV infection and co-morbidities is greatest in the Global South, a large proportion of HIV mental health research is carried out in the Global North. Large, well-funded observational cohort studies exploring HIV-associated psychopathology generally involve participant groups from WEIRD (Western, educated, industrialised, rich and democratic) settings. The socioeconomic status and institutional access afforded to these participant groups on average does not reflect those of the majority of beneficiaries of HIV mental health research. This misalignment may lead to limitations in generalising findings and developing effective interventions to improve the mental health of PLWH. Here, I offer recommendations to actively cultivate authentic diversity and inclusion in the field, with four focus points: (1) for funding bodies, to actively invest in neuroscientists in the Global South for investigations of HIV-related psychopathology; (2) for scientific publishers, to fund professional support services for researchers in the Global South; (3) for academic institutions, to facilitate meaningful, equitable collaborations with researchers in the Global South and incentivise studies with diverse participant groups; and (4) for individual neuroscientists, to actively cite and converse with colleagues in the Global South, tackle personal biases in those conversations, and avoid overgeneralising findings from primarily WEIRD participant groups.

摘要

大脑仍然是潜伏性 HIV 感染的主要储存库,HIV 感染者(PLWH)面临认知障碍和精神障碍的高风险。尽管 HIV 感染和合并症的负担在全球南方最大,但大部分 HIV 心理健康研究是在全球北方进行的。探索与 HIV 相关的精神病理学的大型、资金充足的观察性队列研究通常涉及来自 WEIRD(西方、受过教育、工业化、富有和民主)环境的参与者群体。这些参与者群体的社会经济地位和机构准入平均反映了 HIV 心理健康研究的大多数受益人的情况。这种不匹配可能导致在推广研究结果和开发有效的干预措施以改善 PLWH 的心理健康方面存在局限性。在这里,我提出了在该领域积极培养真实多样性和包容性的建议,重点有四点:(1)对于资助机构,积极投资于全球南方的神经科学家,以研究与 HIV 相关的精神病理学;(2)对于科学出版商,为全球南方的研究人员提供专业的支持服务;(3)对于学术机构,促进与全球南方研究人员的有意义、公平的合作,并激励具有不同参与者群体的研究;(4)对于个体神经科学家,积极与全球南方的同事交流,解决这些对话中的个人偏见,并避免从主要由 WEIRD 参与者群体得出的结论过度推广。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88dd/9763108/7729cc1e67fe/41380_2022_1748_Fig1_HTML.jpg

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