John Elizabeth S, Chokhavatia Sita
Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, 1 RWJ Place, New Brunswick, NJ, 08901, USA.
Valley Medical Group, Ridgewood, NJ, USA.
Curr Gastroenterol Rep. 2017 Jul;19(7):31. doi: 10.1007/s11894-017-0573-x.
BACKGROUND: The options for the treatment of diarrhea and constipation are evolving as emerging therapies target small bowel receptors. The goal of this review is to discuss small bowel receptors involved in intestinal absorption, secretion, and motility. The review highlights therapies already approved or currently being studied for the modulation of these receptors. METHODS: The articles cited in this review focus on the molecular level of pathways involved in diarrhea and constipation, and highlight the respective pharmacotherapies. RESULTS: The majority of the studies in the current literature investigate the effects of both the small and large intestine receptors on diarrhea and constipation. There are fewer studies that isolate the effects of these receptors solely on the small bowel, and focusing more on the receptors found distinctly in the small intestine may be an area of interest for future studies as this can inspire more targeted therapies.
背景：随着新兴疗法针对小肠受体，腹泻和便秘的治疗选择不断演变。本综述的目的是讨论参与肠道吸收、分泌和运动的小肠受体。该综述重点介绍了已获批或正在研究的用于调节这些受体的疗法。 方法：本综述引用的文章聚焦于腹泻和便秘所涉及途径的分子水平，并重点介绍了相应的药物治疗方法。 结果：当前文献中的大多数研究调查了小肠和大肠受体对腹泻和便秘的影响。单独研究这些受体对小肠的影响的研究较少，更多地关注小肠中特有的受体可能是未来研究的一个感兴趣领域，因为这可以激发更有针对性的疗法。
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