Si Lei, Shi Lei, Chen Mingsheng, Palmer Andrew J
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia.
School of Health Administration, Anhui Medical University, Hefei, Anhui, 230032, China.
Qual Life Res. 2017 Nov;26(11):3049-3058. doi: 10.1007/s11136-017-1614-5. Epub 2017 Jun 7.
Despite a flurry of cost utility analyses conducted in the Chinese population in recent years, a standard set of health state utilities (HSUs) for the Chinese population is lacking. The aims of this study were to (1) determine benchmark age- and sex-specific HSUs for a Chinese population, and (2) assess key correlates of HSUs in this population.
Quality-of-life was evaluated using the validated EQ-5D-3L questionnaire. HSUs were calculated using data collected from Gansu Province (n = 9833). Overall differences in HSUs were analysed using linear regression and a two-tailed p value <0.05 was determined to be statistically significant. The minimal difference in weighted index was set at 0.074.
HSUs decreased with age in both males and females. Living in the non-capital areas, being separated/divorced/widowed or never married, being never educated, diagnosed with chronic disease, and no regular physical activity were associated with lower HSUs. HSUs for women were lower than for men in univariate regression analysis; however, no differences were found after adjusting for other covariates. In addition, the difference in HSU reached the level of minimal difference in weighted index for participants with chronic disease. HSUs for those who were diagnosed with chronic disease were 0.098 (0.092-0.104) lower than those without chronic disease.
This study reports HSUs for a Chinese population in Gansu and investigates the key correlates of HSUs in this population. In addition, the use of EQ-5D-3L in assessing population health is limited given the high ceiling effect and skewed HSUs.
尽管近年来针对中国人群进行了一系列成本效用分析，但仍缺乏一套针对中国人群的标准健康状态效用值（HSU）。本研究的目的是：（1）确定中国人群按年龄和性别划分的基准HSU，以及（2）评估该人群中HSU的关键相关因素。
使用经过验证的EQ-5D-3L问卷评估生活质量。HSU通过从甘肃省收集的数据（n = 9833）计算得出。使用线性回归分析HSU的总体差异，将双侧p值<0.05确定为具有统计学意义。加权指数的最小差异设定为0.074。
男性和女性的HSU均随年龄增长而下降。居住在非省会地区、分居/离婚/丧偶或从未结婚、未受过教育、被诊断患有慢性病以及没有定期体育活动与较低的HSU相关。单因素回归分析中女性的HSU低于男性；然而，在调整其他协变量后未发现差异。此外，患有慢性病的参与者的HSU差异达到了加权指数的最小差异水平。被诊断患有慢性病的人的HSU比没有慢性病的人低0.098（0.092 - 0.104）。
本研究报告了甘肃省中国人群的HSU，并调查了该人群中HSU的关键相关因素。此外，鉴于高天花板效应和HSU的偏态分布，EQ-5D-3L在评估人群健康方面的应用有限。
