Droin Nathalie, Lucas Nolwenn, Parinet Vincent, Selimoglu-Buet Dorothée, Humbert Marc, Saada Véronique, Lambotte Olivier, Solary Eric, Noël Nicolas
a INSERM U1170, Gustave Roussy , Villejuif , France.
b Département d'Hématologie Clinique , Gustave Roussy , Villejuif , France.
Leuk Lymphoma. 2017 Dec;58(12):2875-2879. doi: 10.1080/10428194.2017.1330468. Epub 2017 Jun 8.
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder that associates dysplastic and proliferative features. Tissue inflammatory disorders occur in a fraction of CMML patients during the course of their disease. Here, we describe the occurrence of eosinophil-rich tissue inflammation, including eosinophilic pneumonia, chondritis, and cystitis, in CMML patients. Whole exome sequencing of leukemic cells did not identify a recurrent genetic abnormality among these three patients who were clinically improved by local or oral corticosteroids. Hypomethylating drugs were subsequently added in two of them, allowing decreasing corticosteroid doses and further treating their hematopoietic malignancy.
慢性粒单核细胞白血病（CMML）是一种伴有发育异常和增殖特征的克隆性造血疾病。部分CMML患者在病程中会出现组织炎症性疾病。在此，我们描述了CMML患者中富含嗜酸性粒细胞的组织炎症的发生情况，包括嗜酸性粒细胞性肺炎、软骨炎和膀胱炎。对白血病细胞进行的全外显子组测序在这三名经局部或口服皮质类固醇治疗后临床症状改善的患者中未发现复发性基因异常。随后，其中两名患者加用了去甲基化药物，从而得以降低皮质类固醇剂量并进一步治疗其造血系统恶性肿瘤。
