Hyde Jason, Sun Tsieh
Department of Pathology, University of Colorado Health Science Center, Denver, CO 80262, USA.
Arch Pathol Lab Med. 2003 Sep;127(9):1214-6. doi: 10.5858/2003-127-1214-CMLWAB.
Chronic myelomonocytic leukemia with eosinophilia is a recently defined rare entity frequently associated with t(5;12)(q33;p13) translocation. It usually shows a peripheral eosinophil count greater than 1500/microL. However, the literature contains a small subset of cases in which the major manifestation is bone marrow eosinophilia. We report a case similar to that subset and discuss our finding that the immature eosinophils are identical to those seen in acute myelomonocytic leukemia with abnormal bone marrow eosinophils.
伴有嗜酸性粒细胞增多的慢性粒单核细胞白血病是一种最近定义的罕见疾病，常与t(5;12)(q33;p13)易位相关。其外周血嗜酸性粒细胞计数通常大于1500/微升。然而，文献中有一小部分病例主要表现为骨髓嗜酸性粒细胞增多。我们报告了一例类似该亚组的病例，并讨论了我们的发现，即未成熟嗜酸性粒细胞与骨髓嗜酸性粒细胞异常的急性粒单核细胞白血病中所见的嗜酸性粒细胞相同。
