Department of Allergology, University General Hospital, Valencia, Valencia, Spain.
Department of Pediatric Allergy, Gregorio Marañón Hospital, Madrid, Spain.
J Investig Allergol Clin Immunol. 2017;27(5):279-290. doi: 10.18176/jiaci.0178. Epub 2017 Jun 8.
Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts.
A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC.
Recommendations were established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of adverse reactions.
Clinical practice guidelines based on the consensus reached between Spanish experts are presented for the management of OIT with milk and egg.
牛奶和鸡蛋是生命最初几年中最常见的食物过敏原因。口服免疫疗法（OIT）已被研究作为避免饮食的替代方法。目前尚无关于牛奶和鸡蛋 OIT 管理的临床实践指南。目的：根据现有科学证据和专家意见制定 OIT 的临床指南。
回顾了 1984 年至 2016 年 6 月期间发表的研究、在西班牙发表的博士论文、科学会议的会议摘要（SEAIC、SEICAP、EAACI 和 AAAAI）以及 SEICAP 和 SEAIC 科学协会的一组专家达成的共识意见。
制定了关于 OIT 的不同阶段的适应证、要求和实际方面的建议，以及对高不良反应风险患者的特殊方案。
提出了基于西班牙专家达成的共识的临床实践指南，用于管理牛奶和鸡蛋的 OIT。
