Martorell A, Alonso E, Echeverría L, Escudero C, García-Rodríguez R, Blasco C, Bone J, Borja-Segade J, Bracamonte T, Claver A, Corzo J L, De la Hoz B, Del Olmo R, Dominguez O, Fuentes-Aparicio V, Guallar I, Larramona H, Martín-Muñoz F, Matheu V, Michavila A, Ojeda I, Ojeda P, Piquer M, Poza P, Reche M, Río P Rodríguez Del, Rodríguez M, Ruano F, Sánchez-García S, Terrados S, Valdesoiro L, Vazquez-Ortiz M
Department of Allergology, University General Hospital, Valencia, Spain.
Department of Pediatric Allergy, Gregorio Marañón Hospital, Madrid, Spain.
Allergol Immunopathol (Madr). 2017 Sep-Oct;45(5):508-518. doi: 10.1016/j.aller.2017.05.002. Epub 2017 Jul 1.
Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available.
To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts.
A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC.
Recommendations have been established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of suffering adverse reactions.
A clinical practice guide is presented for the management of OIT with milk and egg, based on the opinion consensus of Spanish experts.
牛奶和鸡蛋是婴儿期最常见的食物过敏诱因。口服免疫疗法（OIT）等治疗方法已被研究作为回避饮食的替代方案。目前尚无关于牛奶和鸡蛋口服免疫疗法管理的临床实践指南。
基于现有科学证据和专家意见制定口服免疫疗法临床指南。
对1984年至2016年6月期间发表的研究、西班牙发表的博士论文以及大会（SEAIC、SEICAP、EAACI、AAAI）交流摘要进行综述，并评估与科学协会SEICAP和SEAIC相关的一组专家达成的意见共识。
已就口服免疫疗法不同阶段的适应症、要求和实际方面以及不良反应高风险患者的特殊方案提出建议。
基于西班牙专家的意见共识，提出了牛奶和鸡蛋口服免疫疗法管理的临床实践指南。
