用于生物成像的无螯合剂且生物相容性良好的黑色素纳米平台，可轻松负载钆和铜-64
Chelator-Free and Biocompatible Melanin Nanoplatform with Facile-Loading Gadolinium and Copper-64 for Bioimaging.
作者信息
Hong Su Hyun, Sun Yao, Tang Chu, Cheng Kai, Zhang Ruiping, Fan Quli, Xu Liying, Huang Daijuan, Zhao Anthony, Cheng Zhen
机构信息
Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University , 1201 Welch Road, Lucas Center, P095, Stanford, California 94305, United States.
Department of Chemistry, Stanford University , William Keck Science Building, Room 125, Stanford, California 94305, United States.
出版信息
Bioconjug Chem. 2017 Jul 19;28(7):1925-1930. doi: 10.1021/acs.bioconjchem.7b00245. Epub 2017 Jun 22.
Development of a chelator-free and biocompatible platform for the facile construction of gadolinium (Gd)-loaded nanoparticle based probes for in vivo magentic resonance imaging (MRI) is still challenging. Herein, biocompatible Gd-loading melanin dots (Gd-M-dots) have been easily prepared and have exhibited good loading efficiency for Gd, high stability, and higher T relaxivity compared to the commercial Gd-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) agent. Furthermore, Gd-M-dots showed unique photoacoustic (PA) properties, and a high PA imaging signal could be observed in vivo 1 h after injection. Compared to the traditional Gd-loaded nanoparticles for single-modal MRI, Gd-M-dots can also be radiolabeled with Cu for positron emission tomography. Overall, these attractive properties of Gd-M-dots render them a promising imaging agent for various biomedical applications.
开发一种无螯合剂且生物相容性良好的平台，用于轻松构建基于负载钆（Gd）的纳米颗粒的探针以用于体内磁共振成像（MRI），仍然具有挑战性。在此，已轻松制备出生物相容性负载Gd的黑色素点（Gd-M-点），其对Gd表现出良好的负载效率、高稳定性，并且与市售的钆-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸（DOTA）试剂相比具有更高的T弛豫率。此外，Gd-M-点表现出独特的光声（PA）特性，在注射后1小时可在体内观察到高PA成像信号。与用于单模态MRI的传统负载Gd的纳米颗粒相比，Gd-M-点还可以用铜进行放射性标记以用于正电子发射断层扫描。总体而言，Gd-M-点的这些吸引人的特性使其成为用于各种生物医学应用的有前景的成像剂。
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