Farooq Afifa, Sabah Shafiya, Dhou Salam, Alsawaftah Nour, Husseini Ghaleb
Biomedical Engineering Graduate Program, American University of Sharjah, Sharjah 26666, United Arab Emirates.
Department of Computer Science and Engineering, American University of Sharjah, Sharjah 26666, United Arab Emirates.
Nanomaterials (Basel). 2022 Jan 25;12(3):393. doi: 10.3390/nano12030393.
The field of cancer theranostics has grown rapidly in the past decade and innovative 'biosmart' theranostic materials are being synthesized and studied to combat the fast growth of cancer metastases. While current state-of-the-art oncology imaging techniques have decreased mortality rates, patients still face a diminished quality of life due to treatment. Therefore, improved diagnostics are needed to define in vivo tumor growths on a molecular level to achieve image-guided therapies and tailored dosage needs. This review summarizes in vivo studies that utilize contrast agents within the field of photoacoustic imaging-a relatively new imaging modality-for tumor detection, with a special focus on imaging and transducer parameters. This paper also details the different types of contrast agents used in this novel diagnostic field, i.e., organic-based, metal/inorganic-based, and dye-based contrast agents. We conclude this review by discussing the challenges and future direction of photoacoustic imaging.
在过去十年中，癌症诊疗领域发展迅速，人们正在合成和研究创新型“生物智能”诊疗材料，以对抗癌症转移的快速增长。虽然当前最先进的肿瘤成像技术降低了死亡率，但患者仍因治疗而面临生活质量下降的问题。因此，需要改进诊断方法，以便在分子水平上定义体内肿瘤生长情况，从而实现图像引导治疗和个性化剂量需求。本综述总结了在光声成像领域（一种相对较新的成像方式）利用造影剂进行肿瘤检测的体内研究，特别关注成像和换能器参数。本文还详细介绍了在这个新型诊断领域中使用的不同类型的造影剂，即有机基、金属/无机基和染料基造影剂。我们通过讨论光声成像的挑战和未来方向来结束本综述。
