Rahimi Siavash, Marani Carla, Balega Janos, Hirschowitz Lynn
Department of Histopathology (S.R.), Queen Alexandra Hospital, Cosham, PortsmouthPan-Birmingham Gynaecological Cancer Centre (J.B.), City HospitalDepartment of Cellular Pathology (L.H.), Birmingham Women's NHS Trust, Birmingham, UKHistopathology Division (C.M.), Ospedale San Carlo Di Nancy, Rome, Italy.
Int J Gynecol Pathol. 2017 Jul;36(4):334-338. doi: 10.1097/PGP.0000000000000340.
We report 2 cases of vaginal glomangiomyoma in a 53-year-old who presented with a painful vaginal mass, and a 56-year-old who had postmenopausal bleeding and in whom an incidental vaginal mass was identified and resected at the time of hysterectomy. Histologic examination of the resected masses showed solid, circumscribed, benign, smooth muscle-predominant tumors with interspersed small islands of epithelioid glomus cells. The glomus cells were intimately related to small-caliber blood vessels and showed no cytologic atypia or mitotic activity. The tumor cells showed diffuse expression of smooth muscle actin, CD34, and focal expression of h-caldesmon, vimentin, and estrogen receptor. No immunolabeling for calponin B or desmin was found. To our knowledge, there are only isolated reports of vaginal glomus tumors, and these are the first reported case of vaginal glomangiomyoma in the literature.
我们报告了2例阴道血管球性平滑肌瘤病例，1例为53岁，表现为阴道肿物伴疼痛；另1例为56岁，有绝经后出血，在子宫切除时偶然发现并切除了阴道肿物。对切除肿物的组织学检查显示，肿瘤为实性、边界清楚的良性肿瘤，以平滑肌为主，散在分布着小灶性上皮样血管球细胞。血管球细胞与小口径血管关系密切，未见细胞异型性及有丝分裂活性。肿瘤细胞平滑肌肌动蛋白、CD34呈弥漫性表达，h - 钙调蛋白、波形蛋白及雌激素受体呈局灶性表达。未发现钙结合蛋白B或结蛋白的免疫标记。据我们所知，仅有关于阴道血管球瘤的个别报道，而本文是文献中首次报道的阴道血管球性平滑肌瘤病例。
