Nicholson A N, Pascoe P A, Stone B M
Neuropharmacology. 1985 Mar;24(3):245-50. doi: 10.1016/0028-3908(85)90081-4.
Effects of H1 (mepyramine, mequitazine, triprolidine and brompheniramine) and H2 (cimetidine and ranitidine) antagonists on sleep were studied in healthy man. There were no effects of mepyramine (50 and 100 mg), and the only effect of mequitazine (5 and 10 mg) was a reduction in the number of awakenings. Triprolidine (10 and 20 mg) and brompheniramine (4 and 8 mg) did not alter wakefulness during sleep or the total sleep time, but rapid eye movement sleep was reduced. There were no effects of ranitidine (150 and 300 mg), but slow wave sleep was increased by cimetidine (200 and 400 mg). It is tentatively suggested that the histaminergic system is concerned with the mechanisms which favour vigilance during the wakeful state, and the balance between wakefulness and slow wave activity during sleep. Effects of some H1 antihistamines on rapid eye movement sleep are believed to be due to their monoaminergic rather than their histaminergic activity.
在健康男性中研究了H1（美吡拉敏、美喹他嗪、曲普利啶和溴苯那敏）和H2（西咪替丁和雷尼替丁）拮抗剂对睡眠的影响。美吡拉敏（50和100毫克）无作用，美喹他嗪（5和10毫克）唯一的作用是减少觉醒次数。曲普利啶（10和20毫克）和溴苯那敏（4和8毫克）不改变睡眠期间的清醒状态或总睡眠时间，但快速眼动睡眠减少。雷尼替丁（150和300毫克）无作用，但西咪替丁（200和400毫克）可增加慢波睡眠。初步认为，组胺能系统与清醒状态下促进警觉的机制以及睡眠期间清醒与慢波活动之间的平衡有关。一些H1抗组胺药对快速眼动睡眠的影响被认为是由于它们的单胺能活性而非组胺能活性。
