Gilani Sadaf J, Jafar Mohammed, Shakil Kashif, Imam Syed S
Glocal School of Pharmacy, Glocal University, Saharanpur-247121, Uttar Pradesh, India.
College of Pharmacy, Al-Jouf University, Aljouf, Saudi Arabia.
Recent Pat Antiinfect Drug Discov. 2017;12(2):95-106. doi: 10.2174/1574891X12666170427120230.
Nano size based drug delivery systems are an emerging technique with the potential to develop new strategies involving handling of drugs at the nanometer scale. There are many nano-based drug delivery systems that have been extensively reported as drug carriers for the treatment of tuberculosis.
There are numerous nano sized drug delivery systems like lipid nanoparticles, polymeric micelle, carbon nanotubes and polymeric nanoparticles that have been reported for a long time to treat diseases. There are a number of drawbacks in conventional TB dosage forms such as the development of multiple drug resistance, resulting in intolerable toxicity and high drug dose required. So, to overcome the drawbacks of conventional therapy, there is a need for a new drug delivery system with an aim to reduce the side effects of drug treatment. Nano-sized based drug delivery systems have considerable potential for the treatment of tuberculosis. These delivery systems have several advantages like high stability, high loading capacity, the feasibility of incorporation of both hydrophilic and hydrophobic drugs, and feasibility of variable routes of administration, and prolonged drug release from the matrix. These advantages enable enhanced drug solubility, bioavailability, reduced dosing frequency, high targeting, and may resolve the problem of non adherence to prescribed therapy, which is one of the major obstacles in the control of tuberculosis epidemics.
This article gives an exhaustive review of patents and research papers published over the years on the challenges, the current treatment therapy of the disease faces, and potential advantages of nano sized formulations to offer more effective treatment and prevention for tuberculosis.
基于纳米尺寸的药物递送系统是一种新兴技术，有潜力开发涉及在纳米尺度处理药物的新策略。有许多基于纳米的药物递送系统已被广泛报道可作为治疗结核病的药物载体。
有许多纳米尺寸的药物递送系统，如脂质纳米颗粒、聚合物胶束、碳纳米管和聚合物纳米颗粒，长期以来一直被报道用于治疗疾病。传统结核病剂型存在许多缺点，如多重耐药性的产生，导致难以忍受的毒性和所需的高药物剂量。因此，为了克服传统疗法的缺点，需要一种新的药物递送系统，以减少药物治疗的副作用。基于纳米尺寸的药物递送系统在治疗结核病方面具有相当大的潜力。这些递送系统具有几个优点，如高稳定性、高载药量、可同时包载亲水性和疏水性药物、多种给药途径的可行性以及从基质中延长药物释放。这些优点能够提高药物溶解度、生物利用度、减少给药频率、实现高靶向性，并可能解决不遵守规定治疗方案的问题，这是控制结核病流行的主要障碍之一。
本文对多年来发表的专利和研究论文进行了详尽综述，内容涉及该疾病面临的挑战、当前治疗方法以及纳米制剂的潜在优势，旨在为结核病提供更有效的治疗和预防方法。
