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宫内节育器及输卵管结扎或堵塞的使用趋势与并发症

Trends in use of and complications from intrauterine contraceptive devices and tubal ligation or occlusion.

作者信息

Howard Brandon, Grubb ElizaBeth, Lage Maureen J, Tang Boxiong

机构信息

Teva Global Medical Affairs, 41 Moores Road, Frazer, PA, 19355, USA.

Teva Global Health Economics & Outcomes Research, 11100 Nall Ave, Overland Park, KS, 66211, USA.

出版信息

Reprod Health. 2017 Jun 8;14(1):70. doi: 10.1186/s12978-017-0334-1.

Abstract

BACKGROUND

Long-acting reversible contraceptives such as intrauterine devices (IUDs) are highly effective in preventing pregnancy, cost effective, and increasing in popularity. It is unclear whether changes in IUD use are associated with changes in rates of irreversible tubal sterilization. In this analysis, we evaluate changes in rates of tubal sterilization, insertion of copper or levonorgestrel (LNG) IUDs, and related complications over time.

METHODS

Data were obtained from a retrospective claims database (Optum Clinformatics Data Mart) of women aged 15 to 45 years who underwent insertion of copper or LNG IUD or tubal sterilization between 1/1/2006 and 12/31/2011. Outcomes of interest included annual rates of insertion or sterilization and annual rates of potential complications and side effects.

RESULTS

The number of women included in the analysis each year ranged from 1,870,675 to 2,016,916. Between 2006 and 2011, copper IUD insertion claim rates increased from 0.18 to 0.25% and LNG IUD insertion claim rates increased from 0.63 to 1.15%, while sterilization claims decreased from 0.78 to 0.66% (P < 0.0001 for all comparisons). Increases in IUD insertion were apparent in all age groups; decreases in tubal sterilization occurred in women aged 20 to 34 years. The most common side effects and complications were amenorrhea (7.36-11.59%), heavy menstrual bleeding (4.85-15.69%), and pelvic pain (11.12-14.27%). Significant increases in claims of certain complications associated with IUD insertion or sterilization were also observed.

CONCLUSION

Between 2006 and 2011, a decrease in sterilization rates accompanied an increase in IUD insertion rates, suggesting that increasing numbers of women opted for reversible methods of long-term contraception over permanent sterilization.

摘要

背景

长效可逆避孕方法,如宫内节育器(IUD),在预防妊娠方面非常有效,具有成本效益,且越来越受欢迎。目前尚不清楚宫内节育器使用的变化是否与不可逆输卵管绝育率的变化相关。在本分析中,我们评估了输卵管绝育率、铜或左炔诺孕酮(LNG)宫内节育器的植入率以及相关并发症随时间的变化。

方法

数据来自一个回顾性索赔数据库(Optum临床信息数据集市),该数据库涵盖了2006年1月1日至2011年12月31日期间年龄在15至45岁之间接受铜或LNG宫内节育器植入或输卵管绝育的女性。感兴趣的结果包括每年的植入或绝育率以及每年潜在并发症和副作用的发生率。

结果

每年纳入分析的女性人数在1,870,675至2,016,916之间。2006年至2011年期间,铜宫内节育器植入索赔率从0.18%增至0.25%,LNG宫内节育器植入索赔率从0.63%增至1.15%,而绝育索赔率从0.78%降至0.66%(所有比较P < 0.0001)。宫内节育器植入率的增加在所有年龄组中都很明显;20至34岁女性的输卵管绝育率有所下降。最常见的副作用和并发症是闭经(7.36 - 11.59%)、月经过多(4.85 - 15.69%)和盆腔疼痛(11.12 - 14.27%)。与宫内节育器植入或绝育相关的某些并发症的索赔也有显著增加。

结论

2006年至2011年期间,绝育率下降,同时宫内节育器植入率上升,这表明越来越多的女性选择可逆的长期避孕方法而非永久性绝育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec56/5465441/0135d483233b/12978_2017_334_Fig1_HTML.jpg

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