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生殖手术后的自然妊娠率。

Spontaneous pregnancy rates after reproductive surgery.

作者信息

Ban Frangez Helena, Korošec Sara, Pozlep Barbara, Jancar Nina, Salamun Vesna, Vogler Andrej, Burnik Papler Tanja, Cvetko Tea Terezija, Vrtacnik Bokal Eda

机构信息

Department of Human Reproduction, Division of Gynaecology, University Medical Center Ljubljana, Slajmerjeva 3, Slovenia.

Department of Human Reproduction, Division of Gynaecology, University Medical Center Ljubljana, Slajmerjeva 3, Slovenia.

出版信息

Reprod Biomed Online. 2017 Aug;35(2):165-173. doi: 10.1016/j.rbmo.2017.05.007. Epub 2017 May 22.

Abstract

With the development of IVF procedures, the role of reproductive surgery in the management of infertile couples has been questioned. Pregnancy rates (PR) after IVF procedures are well known, but recent data on spontaneous PR after reproductive surgery are scarce. This study aimed to prospectively evaluate how often fertility is restored by reproductive surgery and to identify which independent factors influence spontaneous pregnancy after reproductive surgery. Eight hundred eighty-eight infertile women who underwent surgery for infertility were prospectively included. Women who were referred to IVF after surgery, ceased to plan pregnancy and were lost to follow-up were excluded. Spontaneous PR was analysed for 519 women. A total of 252 (48.6%) women, including 30 treated with clomiphene citrate, conceived spontaneously in the 12-18 months observation period following surgery. Multivariate logistic regression showed that woman's age (OR 0.95, 95% CI 0.90-0.99) and duration of infertility (OR 0.86, 95% CI 0.74-0.99) significantly influence spontaneous PR. Each year of infertility lowers spontaneous PR following surgery by 14% and each year of woman's age by 5%. The study shows a relatively high percentage of women conceived spontaneously after reproductive surgery. The role of reproductive surgery in the management of infertility should be re-evaluated.

摘要

随着体外受精(IVF)技术的发展,生殖手术在不孕夫妇治疗中的作用受到了质疑。IVF术后的妊娠率(PR)是众所周知的,但关于生殖手术后自然妊娠率的最新数据却很稀少。本研究旨在前瞻性评估生殖手术恢复生育能力的频率,并确定哪些独立因素会影响生殖手术后的自然妊娠。前瞻性纳入了888名因不孕接受手术的不孕女性。排除术后转诊至IVF、停止计划妊娠并失访的女性。对519名女性的自然PR进行了分析。在术后12至18个月的观察期内,共有252名(48.6%)女性自然受孕,其中包括30名接受枸橼酸氯米芬治疗的女性。多因素逻辑回归分析显示,女性年龄(OR 0.95,95%CI 0.90 - 0.99)和不孕持续时间(OR 0.86,95%CI 0.74 - 0.99)对自然PR有显著影响。不孕时间每增加一年,术后自然PR降低14%,女性年龄每增加一岁,术后自然PR降低5%。该研究表明,生殖手术后自然受孕的女性比例相对较高。应重新评估生殖手术在不孕治疗中的作用。

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