Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, Kerala, India.
Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, Kerala, India.
Bioresour Technol. 2017 Dec;245(Pt B):1775-1781. doi: 10.1016/j.biortech.2017.05.057. Epub 2017 May 12.
L-asparaginase is one of the protein drugs for countering leukemia and lymphoma. A major challenge in the therapeutic potential of the enzyme is its immunogenicity, low-plasma half-life and glutaminase activity that are found to be the reasons for toxicities attributed to asparaginase therapy. For addressing these challenges, several research and developmental activities are going on throughout the world for an effective drug delivery for treatment of cancer. Hence there is an urgent need for the development of asparaginase with improved properties for efficient drug delivery. The strategies selected should be economically viable to ensure the availability of the drug at low cost. The current review addresses various strategies adopted for the production of asparaginase from different sources, approaches for increasing the therapeutic efficiency of the protein and new drug delivery systems for L-asparaginase.
L-天冬酰胺酶是一种用于对抗白血病和淋巴瘤的蛋白质药物。该酶的治疗潜力面临的主要挑战是其免疫原性、低血浆半衰期和谷氨酰胺酶活性，这些被认为是导致天冬酰胺酶治疗毒性的原因。为了应对这些挑战，全世界正在进行多项研究和开发活动，以寻找有效的药物输送系统来治疗癌症。因此，迫切需要开发具有改善性能的天冬酰胺酶，以实现高效的药物输送。选择的策略应该具有经济可行性，以确保以低成本提供药物。本综述讨论了从不同来源生产天冬酰胺酶所采用的各种策略、提高蛋白质治疗效率的方法以及 L-天冬酰胺酶的新型药物输送系统。
