精神分裂症患者与正常人脑脊液中胆囊收缩素、蛙皮素和生长抑素的研究

Cerebrospinal fluid cholecystokinin, bombesin and somatostatin in schizophrenia and normals.

作者信息

Gerner R H, van Kammen D P, Ninan P T

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(1):73-82. doi: 10.1016/0278-5846(85)90181-2.

Abstract

Cerebrospinal fluid from 31 normals and two groups of phenomenologically similar schizophrenics (n = 72) were collected by identical methods. Radioimmunoassay of CSF was carried out for somatostatin, bombesin, and cholecystokinin. One group of schizophrenics had increased baseline somatostatin and cholecystokinin, and decreased bombesin. No CSF gradient effect was found for the peptides nor were their levels affected by probenecid or pimozide treatment. An inverse correlation was found between bombesin and psychosis rating. Intercorrelation between the peptides and HVA, 5-HIAA, and MHPG were not significant.

摘要

采用相同方法收集了31名正常人以及两组现象学上相似的精神分裂症患者（n = 72）的脑脊液。对脑脊液进行了生长抑素、蛙皮素和胆囊收缩素的放射免疫分析。一组精神分裂症患者的基础生长抑素和胆囊收缩素水平升高，蛙皮素水平降低。未发现这些肽存在脑脊液梯度效应，其水平也不受丙磺舒或匹莫齐特治疗的影响。发现蛙皮素与精神病评定之间呈负相关。这些肽与高香草酸、5-羟吲哚乙酸和3-甲氧基-4-羟基苯乙二醇之间的相互关系不显著。