Doran A R, Rubinow D R, Roy A, Pickar D
Arch Gen Psychiatry. 1986 Apr;43(4):365-9. doi: 10.1001/archpsyc.1986.01800040075011.
Low levels of cerebrospinal fluid (CSF) somatostatin and abnormal response to dexamethasone are two neuroendocrine disturbances reported to appear in depression and other neuropsychiatric disorders. We measured the levels of CSF somatostatin in patients with schizophrenia (n = 44) and depression (n = 19). In view of in vitro and animal evidence of the ability of somatostatin to inhibit stimulated corticotropin secretion, we also administered the dexamethasone suppression test to a subgroup of the patients with schizophrenia (n = 16) and the total depressed group. Lower levels of CSF somatostatin were found in dexamethasone nonsuppressors regardless of diagnosis and were negatively correlated with maximum postdexamethasone cortisol level in the total and depressed patient groups. These data suggest a functional relationship between hypothalamic-pituitary-adrenal axis hyperactivity and reduced CSF somatostatin level.
脑脊液（CSF）中生长抑素水平低以及对地塞米松反应异常是据报道在抑郁症和其他神经精神疾病中出现的两种神经内分泌紊乱。我们测量了精神分裂症患者（n = 44）和抑郁症患者（n = 19）脑脊液中生长抑素的水平。鉴于有体外和动物实验证据表明生长抑素具有抑制促肾上腺皮质激素分泌的能力，我们还对一部分精神分裂症患者（n = 16）和全部抑郁症患者进行了地塞米松抑制试验。无论诊断如何，在地塞米松不抑制者中发现脑脊液生长抑素水平较低，并且在全部患者组和抑郁症患者组中，其与地塞米松后皮质醇最高水平呈负相关。这些数据表明下丘脑 - 垂体 - 肾上腺轴功能亢进与脑脊液生长抑素水平降低之间存在功能关系。
