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以阿尔伯特埃希氏菌DM104作为候选活疫苗株对豚鼠进行抗痢疾志贺氏菌4型引起的志贺氏菌病的保护作用。

Protection against shigellosis caused by Shigella dysenteriae serotype 4 in guinea pigs using Escherichia albertii DM104 as a live vaccine candidate strain.

作者信息

Chowdhury Fatema Moni, Rahman Mohammed Ziaur, Sarkar Md Murshed Hasan, Rabbi Fazle, Khan Sirajul Islam, Ahsan Chowdhury Rafiqul, Birkeland Nils-Kåre

机构信息

1 Department of Microbiology, University of Dhaka , Dhaka, Bangladesh.

2 Department of Biology, University of Bergen , Bergen, Norway.

出版信息

Acta Microbiol Immunol Hung. 2017 Jun 1;64(2):151-164. doi: 10.1556/030.64.2017.015. Epub 2017 Jun 9.

Abstract

Recently, we reported the induction of protective immunity by environmental Escherichia albertii strain DM104 against Shigella dysenteriae in guinea pig model. In this study, we assessed three different immunization routes, such as intranasal, oral, and intrarectal routes, and revealed differences in immune responses by measuring both the serum IgG and mucosal IgA antibody titers. Protective efficacy of different routes of immunization was also determined by challenging immunized guinea pigs against live S. dysenteriae. It was found that intranasal immunization showed promising results in terms of antibody response and protective efficacy. All these results reconfirm our previous findings and additionally point out that the intranasal immunization of the environmental E. albertii strain DM104 in guinea pig model can be a better live vaccine candidate against shigellosis.

摘要

最近,我们报道了环境阿尔伯特埃希氏菌DM104菌株在豚鼠模型中诱导针对痢疾志贺氏菌的保护性免疫。在本研究中,我们评估了三种不同的免疫途径,即鼻内、口服和直肠内途径,并通过测量血清IgG和粘膜IgA抗体滴度揭示了免疫反应的差异。还通过用活的痢疾志贺氏菌攻击免疫的豚鼠来确定不同免疫途径的保护效果。结果发现,鼻内免疫在抗体反应和保护效果方面显示出有前景的结果。所有这些结果再次证实了我们之前的发现,并进一步指出,在豚鼠模型中对环境阿尔伯特埃希氏菌DM104菌株进行鼻内免疫可能是一种更好的抗志贺氏菌病活疫苗候选物。

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