阴道微生物组的治疗机会。
Therapeutic Opportunities in the Vaginal Microbiome.
机构信息
Lawson Health Research Institute and Departments of Microbiology and Immunology and Surgery, University of Western Ontario, London, Ontario, Canada.
出版信息
Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.BAD-0001-2016.
The reproductive tract of females lies at the core of humanity. The immensely complex process that leads to successful reproduction is miraculous yet invariably successful. Microorganisms have always been a cause for concern for their ability to infect this region, yet it is other, nonpathogenic microbial constituents now uncovered by sequencing technologies that offer hope for improving health. The universality of species being associated with health is the basis for therapeutic opportunities, including through engineered strains. The manipulation of these and other beneficial constituents of the microbiota and their functionality, as well as their metabolites, forms the basis for new diagnostics and interventions. Within 20 years, we should see significant improvements in how cervicovaginal health is restored and maintained, thus providing relief to the countless women who suffer from microbiota-associated disorders.
女性的生殖道处于人类的核心地位。导致成功繁殖的极其复杂的过程是神奇的，但总是成功的。微生物一直因其感染该区域的能力而令人担忧，但现在测序技术揭示了其他非致病性微生物成分，为改善健康带来了希望。与健康相关的物种的普遍性为治疗机会提供了基础，包括通过工程菌株。这些和其他有益的微生物群及其功能成分的操纵，以及它们的代谢物，为新的诊断和干预措施奠定了基础。在 20 年内，我们应该看到如何恢复和维持宫颈阴道健康方面的显著改善，从而为无数遭受微生物群相关疾病困扰的女性提供缓解。
Zotero 插件